Ch. 1. The Structure and Development of Bone / Sandy C. Marks, Jr. and Donna C. Hermey -- Ch. 2. Regulation of Bone Cell Differentiation and Bone Remodelling by the c-Fos/AP-1 Transcription Factor / Agamemnon E. Grigoriadis, Zhao-Qi Wang and Erwin F. Wagner -- Ch. 3. Biomechanics of Bone / Thomas A. Einhorn -- Ch. 4. The Stem Cell of the Osteoblast / James T. Triffitt -- Ch. 5. The Osteoblast Lineage / Jane E. Aubin and Fina Liu -- Ch. 6. Mechanisms Regulating Osteoblast Proliferation and Differentiation / Gary S. Stein, Jane B. Lian, Janet L. Stein, Andre J. van Wijnen, Baruch Frenkel and Martin Montecino -- Ch. 7. Cells of Bone: Osteoclast Generation / Tatsuo Suda, Nobuyuki Udagawa and Naoyuki Takahashi -- Ch. 8. Osteoclast Function: Biology and Mechanisms / Kalervo Vaananen -- Ch. 9. The Osteocyte / P. J. Nijweide, E. H. Burger, J. Klein Nulend and A. Van der Plas -- Ch. 10. Type I Collagen: Structure, Synthesis, and Regulation / Jerome Rossert and Benoit de Crombrugghe -- Ch. 11. Biochemical Basis of Collagen Metabolites as Bone Turnover Markers / David B. Eyre -- Ch. 12. Bone Matrix Proteoglycans and Glycoproteins / Pamela Gehron Robey -- Ch. 13. Osteopontin / William T. Butler, Amy L. Ridall and Marc D. McKee -- Ch. 14. Skeletal Gla Proteins: Gene Structure, Regulation of Expression, and Function / Patricia Ducy and Gerard Karsenty -- Ch. 15. Alkaline Phosphatase / Paula S. Henthorn -- Ch. 16. Osteoblast Proteinases / Nicola C. Partridge and Sandra K. Winchester -- Ch. 17. Cell Surface Attachment Molecules in Bone / M. A. Horton, P. Townsend and S. Nesbitt -- Ch. 18. Theoretical and Methodological Approach / Susan M. Ott -- Ch. 19. The Biology of the Extracellular Ca[superscript 2+]-Sensing Receptor / Edward M. Brown, H. William Harris, Peter M. Vassilev and Steven C. Hebert -- Ch. 20. Phosphorus Homeostasis and Related Disorders / Marc K. Drezner.

Ch. 21. Magnesium Homeostasis / Robert K. Rude -- Ch. 22. Metals in Bone: Aluminum, Boron, Cadmium, Chromium, Lead, Silicon, and Strontium / Felix Bronner -- Ch. 23. Parathyroid Hormone: Structure-Function Relations and Analog Design / Michael Chorev and Michael Rosenblatt -- Ch. 24. Parathyroid Hormone - Molecular Biology and Regulation / Justin Silver and Henry M. Kronenberg -- Ch. 25. Actions of Parathyroid Hormone / Lorraine A. Fitzpatrick and John P. Bilezikian -- Ch. 26. Parathyroid Hormone-Related Protein: The Gene, Its mRNA Species, and Protein Products / Kai H. Yang and Andrew F. Stewart -- Ch. 27. Parathyroid Hormone-Related Protein: Physiological Actions / J. M. Moseley and T. J. Martin -- Ch. 28. Receptors for Parathyroid Hormone and Parathyroid Hormone-Related Protein / Gino V. Segre -- Ch. 29. PTH and PTHrP and Their Receptors: Evolutionary Aspects / Lawrence E. Mallette -- Ch. 30. Vitamin D Receptor Structure, Expression, and Nongenomic Effects / Anthony W. Norman and Elaine D. Collins -- Ch. 31. Vitamin D Gene Regulation / Sylvia Christakos -- Ch. 32. Photobiology and Noncalcemic Actions of Vitamin D / Michael F. Holick -- Ch. 33. The Structure and Molecular Biology of the Calcitonin Receptor / Steven R. Goldring -- Ch. 34. Calcitonin: Structure, Molecular Biology, and Actions / Kenneth L. Becker, Eric S. Nylen, Regis Cohen and Richard H. Snider, Jr. -- Ch. 35. Amylin and CGRP / Ian R. Reid and Jill Cornish -- Ch. 36. Estrogens and Progestins / Steve A. Harris, Kimberly R. Tau, Russell T. Turner and Thomas C. Spelsberg -- Ch. 37. Thyroid Hormone and Bone / Paula H. Stern -- Ch. 38. Clinical and Basic Aspects of Glucocorticoid Action in Bone / Barbara P. Lukert and Barbara E. Kream -- Ch. 39. Effects of Diabetes and Insulin on Bone Metabolism / Johan Verhaeghe and Roger Bouillon -- Ch. 40. Androgens / Eric S. Orwoll.

Ch. 41. Kinins and Neuropeptides / Ulf H. Lerner -- Ch. 42. Vasoactive Agents and Bone Metabolism / Thomas L. Clemens -- Ch. 43. The Role of Insulin-like Growth Factors and Binding Proteins in Bone Cell Biology / Cheryl A. Conover -- Ch. 44. Platelet-Derived Growth Factor and the Skeleton / Ernesto Canalis and Sheila Rydziel -- Ch. 45. Fibroblast Growth Factor and Vascular Endothelial Cell Growth Factor Families / Marja M. Hurley and Robert Z. Florkiewicz -- Ch. 46. Transforming Growth Factor-[beta] / L. F. Bonewald -- Ch. 47. Bone Morphogenetic Proteins / Vicki Rosen, Karen Cox and Gary Hattersley -- Ch. 48. Colony-Stimulating Factors / Willy Hofstetter, Rolf Felix and Marco G. Cecchini -- Ch. 49. Local Regulators of Bone: IL-1, TNF, Lymphotoxin, Interferon-[gamma], IL-8, IL-10, IL-4, the LIF/IL-6 Family, and Additional Cytokines / Mark C. Horowitz and Joseph A. Lorenzo -- Ch. 50. Interleukin-6-Type Cytokines and Their Receptors / Stavros C. Manolagas, Robert L. Jilka, Teresita Bellido, Charles A. O'Brien and A. Michael Parfitt -- Ch. 51. Prostaglandins and Bone Metabolism / Carol Pilbeam, John R. Harrison and Lawrence G. Raisz -- Ch. 52. Local Regulators of Bone: Epidermal Growth Factor-Transforming Growth Factor-[alpha] / Toshiyuki Yoneda -- Ch. 53. Role of Apoptosis in Local Regulation / Brendan F. Boyce -- Ch. 54. Molecular Basis of PTH Overexpression / Geoffrey N. Hendy and Andrew Arnold -- Ch. 55. The Familial Benign Hypocalciuric Hypercalcemia Syndromes / Hunter Heath III -- Ch. 56. Multiple Endocrine Neoplasia Type 1 / Maria Luisa Brandi, Cesare Bordi, Francesco Tonelli, Alberto Falchetti and Stephen J. Marx -- Ch. 57. Ret Protooncogene Mutations in Multiple Endocrine Neoplasia Type 2 / Robert F. Gagel and Gilbert J. Cote -- Ch. 58. Expression of PTHrP in Disease / David Goltzman and Janet E. Henderson.

Ch. 59. Role of Cytokines, Parathyroid Hormone, and Growth Factors in Malignancy / Gregory R. Mundy -- Ch. 60. Molecular Basis of PTH Underexpression / R. V. Thakker -- Ch. 61. Pseudohypoparathyroidism / Michael A. Levine -- Ch. 62. Other Skeletal Diseases Resulting from G Protein Defects - Fibrous Dysplasia and McCune-Albright Syndrome / Lee S. Weinstein -- Ch. 63. Osteogenesis Imperfecta: Current Concepts / Jay R. Shapiro, Dragon Primorac and David W. Rowe -- Ch. 64. Hereditary Deficiencies in Vitamin D Action / Uri A. Liberman -- Ch. 65. Vitamin D Receptor Gene Alleles and Osteoporosis / Coleman Gross, T. Ross Eccleshall and David Feldman -- Ch. 66. Oncogenic Osteomalacia / Kenneth W. Lyles -- Ch. 67. Osteopetrosis / L. Lyndon Key, Jr. and William L. Ries -- Ch. 68. Hypophosphatasia: Nature's Window on Alkaline Phosphatase Function in Man / Michael P. Whyte -- Ch. 69. Paget's Disease of Bone / Frederick R. Singer and G. David Roodman -- Ch. 70. Pathophysiology of Osteoporosis / Gideon A. Rodan, Lawrence G. Raisz and John P. Bilezikian -- Ch. 71. Pharmacological Mechanisms of Therapeutics: Parathyroid Hormone / Joel S. Finkelstein -- Ch. 72. Calcium / Robert P. Heaney -- Ch. 73. Calcium Receptors as Novel Drug Targets / Edward F. Nemeth -- Ch. 74. Bisphosphonates: Mechanisms of Action and Clinical Use / H. Fleisch -- Ch. 75. Fluoride and the Skeleton / Michael Kleerekoper -- Ch. 76. The Pharmacology of Estrogens in Osteoporosis / Robert Lindsay and Felicia Cosman -- Ch. 77. Pharmacological Mechanisms of Therapeutics: Vitamin D and Analogs / Glenville Jones -- Ch. 78. Calcitonin / Moise Azria and Louis V. Avioli -- Ch. 79. The IGFs as Potential Therapy for Metabolic Bone Diseases / Anna G. Johannson and Clifford J. Rosen -- Ch. 80. Therapeutic Potential of TGF-[beta], BMP, and FGF in the Treatment of Bone Loss / Subburaman Mohan and David J. Baylink.

Ch. 81. Anabolic Steroid Effects on Bone in Women / Azriel Schmidt, Shun-ichi Harada and Gideon A. Rodan -- Ch. 82. Mechanisms of Exercise Effects on Bone / Robert Marcus -- Ch. 83. Molecular Cloning of Peptide Hormones and Their Receptors / Harald Juppner and Abdul-Badi Abou-Samra -- Ch. 84. Transgenic Animals / Stephen Clark and David W. Rowe -- Ch. 85. Use of Cultured Osteoblastic Cells to Identify and Characterize Transcriptional Regulatory Elements / Dwight A. Towler -- Ch. 86. Gene Targeting / Andrew C. Karaplis -- Ch. 87. Signal Transduction in Bone Physiology: Messenger Systems for Parathyroid Hormone / Stephen A. Morris and John P. Bilezikian -- Ch. 88. The Growth and Culture of Bone Cells: Osteoclastic / Yoshiyuki Hakeda and Masayoshi Kumegawa -- Ch. 89. Culture of Osteoblastic Cells / Robert J. Majeska -- Ch. 90. In Vitro Bone Resorption Assays / Richard J. Murrills -- Ch. 91. Bone Formation Assays / Gloria Gronowicz and Lawrence G. Raisz -- Ch. 92. Stem Cell Culture / Shlomo Wientroub and Dov Zipori -- Ch. 93. Measurements of Biochemical Markers: Methods and Limitations / Patrick Garnero and Pierre D. Delmas -- Ch. 94. Clinical Application of Biochemical Markers of Bone Metabolism / Markus J. Seibel and Huibert A. P. Pols -- Ch. 95. Principles of Bone Densitometry / Glen M. Blake and Ignac Fogelman -- Ch. 96. Biopsies / Robert R. Recker -- Ch. 97. Animal Models of Bone Disease / Ann D. Geddes.